KMID : 0988920120100020161
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Intestinal Research 2012 Volume.10 No. 2 p.161 ~ p.167
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Seasonal Variation in Flares of Inflammatory Bowel Disease in a Korean Population
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Jang Jae-Hyun
Lee Su-Hee Sung Jun-Mo Park Jung-Ho Kim Hong-Joo Cho Yong-Kyun Sohn Chong-Il Jeon Woo-Kyu Kim Byung-Ik Park Dong-Il
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Abstract
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Background/Aims: Conflicting data have been reported about the seasonal variation in flare-up of inflammatory bowel disease (IBD). The aim of this study was to assess the occurrence of seasonal variations in flare-up of IBD in the Korean population.
Methods: Patients with IBD, who underwent more than 1 year of follow-up and showed more than 1 episode of flare-up, were included. Flares of disease were refined as follows; receipt of a new prescription and increasing dose of corticosteroids, 5-ASA or immunosuppressant; hospitalized or operated due to development and worsening of symptoms; elevation of inflammatory marker due to worsening of Crohn¡¯s Disease Activity Index (CDAI) or Mayo score. In addition, for patients with more than two episodes of flare-up, they were investigated in a monthly and seasonal pattern.
Results: Of 573 patients with IBD, 46 patients with Crohn¡¯s disease and 61 patients with ulcerative colitis were enrolled. There was no association between month of the year and flare of Crohn¡¯s disease (P=0.06) or ulcerative colitis (P=0.58). Further, no association between season of the year and flare of Crohn¡¯s disease (P=0.06) or ulcerative colitis (P=0.68). However, in Crohn¡¯s disease who experience 2 or more flare-ups, symptoms occurred more frequently during winter, especially December (P=0.029).
Conclusions: In the Korean population, there was no association of seasonal and monthly variation in flares of Crohn¡¯s disease and ulcerative colitis. However, in Crohn¡¯s disease, individuals with 2 flar-up or more, symptoms occurred more frequently during December.
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KEYWORD
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Crohn Disease, Colitis, Ulcerative, Flare, Seasons
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